石玉杰

副研究员 博士

北京大学药学院药物分析学系

E-mail: yujiestone@bjmu.edu.cn

地址：北京市海淀区学院路38号北京大学医学部药学院药物分析

学习经历：

1. 2013/09-2016/07，北京大学，药学院药剂学系，药剂学博士

2. 2002/09-2005/07，北京大学，药学院化学生物学系，药物分析学硕士

3. 1995/09-1999/07，中国药科大学，药物制剂，本科

工作经历：

2025/08-至今，北京大学，药学院，副研究员

2018/07-2020/07，美国哈佛大学，工程与应用科学院，访问学者

2007/08-2025/07，北京大学，药学院，讲师

2005/08-2007/07，北京大学，药学院，助教

研究方向

● 难溶性药物与大分子药物的口服递送

● 药物分析新方法与新技术

代表性论文

1. Shi, Yujie#*, Ningning Shi#, Yuelin Yang#, Zhetao Zheng and Qing Xia*. Unnatural Amino Acid-Based Ionic Liquid Enables Oral Treatment of Nonsense Mutation Disease in Mice. Advanced science, 2024, 11(13):2306792.

2. An Lu#, Kang Du#, Meng Wang#, Zehang Zhu, Lei Lei, Yujie Shi*. Natural endogenous material-based vehicles for delivery of macromolecular drugs. Chinese Journal of Natural Medicines. 2024, 22(12):1163-1176.

3. He Wei*, Shi Yujie*, Ding Qu*. Natural-derived drug carriers (NDDCs) for precision therapy [J]. Chinese Journal of Natural Medicines, 2024, 23(0): 1-2.

4. Yujie Shi*, Xiaona Li. (2023). High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry Method for the Identification and Quantification of Lipids in Liposomes. In: D'Souza, G.G., Zhang, H. (eds) Liposomes. Methods in Molecular Biology, vol 2622. Humana, New York, NY.

5. Lin Zhai#, Yujie Shi#, Yi Yan, An Lu, Xiaoyu Liu, Lei Lei, Yi Sun, Linxia Jiang, Xiangyu Wang, Honggang Qian*, Jiancheng Wang*. Local sustained release of PD-1 monoclonal antibody and lenvatinib by thermo-sensitive hydrogel for improving tumor immunotherapy. Chinese Chemical Letters, 2023, 34(8):108104.

6. Linxia Jiang, Yi Sun, An Lu, Xiangyu Wang, Yujie Shi*. Ionic liquids: promising approach for oral drug delivery. Pharmaceutical Research, 2022, 39(10):2353-2365,

7. Yujie Shi#, An Lu#, Xiangyu Wang, Zakia Belhadja, Jiancheng Wang*, Qiang Zhang*. A review of existing strategies for designing long-acting parenteral formulations: focus on underlying mechanisms, and future perspectives. Acta Pharmaceutica Sinica B, 2021, 11(8):2396-2415.

8. Yujie Shi, Zongmin Zhao, Yongsheng Gao, Daniel C. Pan, Alyssa K. Salinas, Eden E.L. Tanner, Junling Guo, Samir Mitragotri*. Oral delivery of sorafenib through spontaneous formation of ionic liquid nanocomplexes. Journal of Controlled Release, 2020, 322: 602-609.

9. Yujie Shi, Zongmin Zhao, Kevin Peng, Yongsheng Gao, Debra Wu, Jayoung Kim, Samir Mitragotri*. Enhancement of Anticancer Efficacy and Tumor Penetration of Sorafenib by Ionic Liquids. Advanced Healthcare Materials, 2020, 10(2):2001455.

10. Yujie Shi#, Dong Peng#, Dan Wang, Zongmin Zhao, Binlong Chen, Bing He, Yukun Zhu, Kun Wang, Jie Tian*, Qiang Zhang*. Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography. International Journal of Nanomedicine, 2019, 14:9809-9821.

11. Yujie Shi, Zujin Shi, Suxin Li, Yuan Zhang, Bing He, Dong Peng, Jie Tian, Ming Zhao*, Xueqing Wang *, Qiang Zhang. The interactions of single-wall carbon nanohorns with polar epithelium. International Journal of Nanomedicine, 2017, 12:4177-4194.